An insulin pill. That’s what Oramed Pharmaceuticals, a
small Israeli-based company, hopes to offer millions of diabetics by 2016.
“Oral insulin
does not exist in the world today, but we are the furthest advanced in getting
it into the market,” said Nadav Kidron, CEO of Oramed. “We are just about to start a Phase 2 trial in the United States, which
is big news.”
Oramed already completed a successful Phase 2 trial in
South Africa in May 2010, but approval by the U.S.’s Food and Drug
Administration (FDA) is the gold standard in the world of pharmaceuticals. To
attain FDA approval, Oramed hopes to start Phase 2 trials in the U.S. by early
2013, and, if successful, Phase 3 trials approximately a year later.
Why hasn’t anyone invented an insulin pill until now?
Two reasons, Kidron told The Jewish Press:
“First, insulin is a peptide, which is a small
protein, and when you swallow it, it gets degraded by the body’s enzymes.
Second, the size of the insulin – it doesn’t go through the gut wall, and
therefore it doesn’t reach the blood circulation. Think of insulin as a tennis
ball and the gut wall as the net. The ball doesn’t go through the net.”
After 25 years of research, however, a team of
scientists at Hadassah Medical Center in Jerusalem devised means of overcoming
these obstacles. Among the scientists was Dr. Miriam Kidron, Nadav’s mother and
a great-niece of Rabbi Abraham Isaac Kook, Palestine’s first Ashkenazic chief
rabbi. She told her son of the group’s breakthrough and together, in 2006, they
helped found Oramed.
“I’m happy that it’s becoming a reality,” Dr. Kidron
told The Jewish Press. “My goal is that people will be able to buy oral insulin
in the pharmacy. It will be fantastic because a huge amount of people in the
world need this medication.”
According to the American Diabetes Association, over
25 million Americans, or eight percent of the population, currently suffer from
diabetes. Worldwide, the number is approximately 350 million.
Wherever he goes, Nadav Kidron said, people are
excited by Oramed’s work. “It’s a Kiddush Hashem. I think it’s the best way to
show people that Israel is not only about the Palestinian-Israeli conflict.
It’s also about drugs and medications that can change their lives for the
better.”
Although Oramed is currently focusing on its insulin pill, it ultimately
hopes to offer other medicines in oral form as well. “Think about the flu
vaccine,” Nadav Kidron said. “Imagine how many more people would take it if it
were available in pill form. Think about how much money the healthcare system
would save. This is a technology that can revolutionize healthcare in the world
the way we know it.”
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